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23 小时
《Cell子刊》胰腺癌的“新克星”?协和医院发现NFE2阻断或可遏制肝转移
【导读】胰腺癌肝转移是导致预后不良的一个重要因素。肝转移中适应性免疫重塑的细节,尤其是中性粒细胞的作用,仍然难以捉摸。在这项研究中,单细胞测序与空间转录组学相结合的结果显示,与原发肿瘤相比,肝转移瘤表现出更具侵袭性的转录特征和更高水平的免疫抑制。20 ...
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