or prostaglandin E2 (PGE2) by monocytes stimulated by bacterial lipopolysaccharide (an index of COX-2 activity). Other assays are based on measurement of collagen-or arachidonic acid-induced ...

COX-2 levels increase during developmental synaptic remodeling 5 and upregulation of synaptic activity 6. Moreover, COX-2 is involved in the coupling of synaptic plasticity with cerebral blood flow 7.

While COX-2 and its product, prostaglandin E2 (PGE2), are well-known for their involvement in inflammation and tumor growth, new research suggests that NSAIDs may also act through other pathways.