COX-2 levels increase during developmental synaptic remodeling 5 and upregulation of synaptic activity 6. Moreover, COX-2 is involved in the coupling of synaptic plasticity with cerebral blood flow 7.

While COX-2 and its product, prostaglandin E2 (PGE2), are well-known for their involvement in inflammation and tumor growth, new research suggests that NSAIDs may also act through other pathways.

or prostaglandin E2 (PGE2) by monocytes stimulated by bacterial lipopolysaccharide (an index of COX-2 activity). Other assays are based on measurement of collagen-or arachidonic acid-induced ...