A 69-year-old gentleman with non-Hodgkin’s lymphoma (stage I), with baseline fibrotic lung changes on CT, received six cycles of R-PMitCebo chemotherapy containing bleomycin. Three months later he ...

Biochemistry Unit, National Heart and Lung Institute, London. BACKGROUND--Intratracheal instillation of bleomycin into mice leads to deposition of collagen in the lung and fibrosis, but the mechanism ...

We use a syngeneic model of lung cancer and human samples from stage III and IV lung cancer patients to address these questions. Project 3:The goal of this project is to study the role of exosomes in ...

Methods To address this, we performed RNA-seq on FACS sorted lung fibroblasts from naïve animals and at early (day 10) and late time points (day 40) following intranasal IAV infection. Transcriptional ...

Objectives: Various animal models replicate specific aspects of systemic sclerosis (SSc). Our choice for this study is the experimental mouse model of bleomycin-induced skin fibrosis, commonly ...