The researchers found that PGD2 primarily activates DP2 through the Gαi signaling pathway, while indomethacin preferentially activates the β-arrestin pathway. This signaling bias was further ...

The pathway plays a significant role in the production ... Aldosterone production is mediated by a protein called beta-arrestin-1. Aldosterone is secreted by the adrenal cortex and its levels ...

Regulation of G protein-coupled receptor signaling by arrestins: development of arrestin antisense approaches to study arrestin function and receptor specificity. Laboratory of Dr. Jeffrey L. Benovic, ...