The rectangles represent chromosome 15. Hatched chromosomes have a paternal pattern of gene functioning and DNA methylation; open chromosomes have a maternal pattern. Angelman syndrome is caused ...

Angelman Syndrome is a rare genetic disorder caused by UBE3A gene mutations, leading to developmental delays, speech issues, ...

Angelman syndrome (Figure 1 ... In short, imprinting of the same region on chromosome 15 has been implicated for both Angelman and Prader-Willi syndromes. However, it is the loss of the maternal ...

UBE3A is located on chromosome 15. Mutations that delete the gene or change its structure, function or activity can cause Angelman syndrome. In many cases, a mutation develops spontaneously on the ...

but lack features of RS owing to favorable skewing of X-chromosome inactivation. Females with features of Angelman syndrome represent the close clinical overlap during early childhood between the ...

How and where in the genome a cancer chemotherapy agent acts on and 'un-silences' the epigenetically silenced gene that causes Angelman syndrome ... It's not just about the chromosomes, but ...