Prostate cancer (PCa) is one of the most frequently diagnosed malignancies in men. Androgen-deprivation therapy (ADT) is the first-line treatment and fundamental management for men with advanced ...

Competitive androgen receptor antagonists are used to treat prostate cancer but, even in the presence of such drugs, overexpression of androgen receptors can drive cellular proliferation ...

Medically reviewed by Lauren Schlanger, MD Androgen insensitivity is an umbrella term for a number of genetic conditions ...

“One of the key insights this study provides is that testosterone action via androgen signalling is critical in both male and female birds.” “The study illustrates that androgen receptors ...

Furthermore, the androgen receptor knockout mice showed no methylation ... be used to monitor androgen-related conditions, detect hormone abuse, and advance aging research. The androgen clock ...

A PubMed search from January 1980 to September 2004 was carried out using the terms "androgen receptor", "polymorphism", and "prostate cancer". In addition, searches were done for the androgen ...

A protein called the androgen receptor normally functions ... is activated by androgens or sex hormones like testosterone, which triggers the receptor to bind to DNA, causing the expression ...

"Importantly, when we removed the receptor protein from mice that binds ... and not some other male factor." High levels of androgen hormone are what makes the average male stronger and faster ...

Researchers from the University of Otago – Ōtākou Whakaihu Waka have created a world-first epigenetic tool which has ...

To do this, they developed the "Androgen Clock," an analysis platform which examines specific DNA regions that change over time in the presence of androgens. While researchers have not yet been able ...

The testes of normal 46,XY males secrete both Müllerian Inhibiting Substance (also known as MIS or antimüllerian hormone ... is the result of normal androgen secretion in the first stage ...