A man who should have developed early-onset Alzheimer's disease due to a genetic mutation is still symptom-free in his 70s.

In addition to the formation of senile plaques and neurofibrillary tangles in brain, the pathological hallmarks of Alzheimer disease (AD), there is substantial neuronal and synaptic loss in the ...

During her talk, Rice had described how a peptide called amyloid precursor protein (APP) gets broken down in the brain into smaller pieces such as amyloid-β, the peptide that notoriously goes on to ...

A recent study published in eLife offers a new perspective on the development of Alzheimer’s disease, suggesting that the ...

Researchers at Washington University School of Medicine in St. Louis have conducted a longitudinal study on an individual ...

Increasing focus is now being placed on the production of Aβ – a process called proteolysis, during which a precursor protein called amyloid precursor protein (APP) is trimmed by an enzyme ...

Two main protein structures are associated with Alzheimer’s disease: amyloid-beta plaques and neurofibrillary tangles (NFTs).

A groundbreaking study reveals how a rare combination of genetics, proteomics, and environmental factors may hold the key to ...

Progress in deciphering the fundamental biological mechanism of Alzheimer's disease (AD) is proceeding at an impressive pace. A consensus has emerged among many investigators that cerebral ...

A single injection of Alnylam’s RNA interference candidate ALN-APP – which is designed to switch off the production of amyloid precursor protein (APP) in the central nervous system – was ...

The double transgenic is more commonly used than either of the parental lines (TAS10 and TPM). TASTPM mice develop several AD-related phenotypes, including age-related amyloid pathology and memory ...

Two main protein structures are associated with Alzheimer’s disease: amyloid-beta plaques and neurofibrillary tangles (NFTs). Amyloid-beta: As Alzheimer’s disease develops, amyloid precursor ...