First generation vectors may be suitable for applications where transient, high level activity is sufficient, and where immune responses to the vector or transgene are acceptable. Adenoviral vectors ...

Ad5 vectors are the most commonly used adenovirus vector. Ad5 vectors transduce a wide range of cell types. They utilize the Coxsackie-Adenovirus Receptor (CAR) to enter cells. Transduction efficiency ...

For recurrent respiratory papillomatosis (RRP), novel gene therapy to jump-start immunity to the human papillomavirus (HPV) ...

Suresh Mittal, Distinguished Professor of Virology in the College of Veterinary Medicine, presented “Universal Influenza Vaccine — An Aspiration or Reality?” at the Westwood Lecture Series on Jan. 28.

with helper adenovirus infection enabling vector production in mammalian cells. This method offered good proof-of-concept, but was too inefficient for large-scale manufacturing. What’s more ...

Example for viral gene therapy using an Adenovirus vector. A new gene is inserted into an adenovirus vector, which is used to introduce the modified DNA into a human cell. If the treatment is ...

Recurrent respiratory papillomatosis (RRP) is a disease of the upper airway presenting with exophytic wart-like lesions. These lesions are considered benign with less than a 1–5% chance of malignant ...